Download Pharmacodynamic Characteristics of Lixisenatide Once Daily Versus Liraglutide Once Daily in Patients with Type 2 Diabetes Insufficiently Controlled on Metformin Books PDF Free

Pharmacodynamic Characteristics of Lixisenatide Once Daily Versus Liraglutide Once Daily in Patients with Type 2 Diabetes Insufficiently Controlled on Metformin PDF
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ABSTRACT Aim Assess the pharmacodynamics of lixisenatide once daily (QD) versus liraglutide QD in type 2 diabetes insufficiently controlled on metformin. Methods In this 28‐day, randomized, open‐label, parallel‐group, multicentre study (NCT01175473), patients (mean HbA1c 7.3%) received subcutaneous lixisenatide QD (10 μg weeks 1–2, then 20 μg; n = 77) or liraglutide QD (0.6 mg week 1, 1.2 mg week 2, then 1.8 mg; n = 71) 30 min before breakfast. Primary endpoint was change in postprandial plasma glucose (PPG) exposure from baseline to day 28 during a breakfast test meal. Results Lixisenatide reduced PPG significantly more than liraglutide [mean change in AUC0:30–4:30h: −12.6 vs. −4.0 h·mmol/L, respectively; p

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Download Pharmacodynamic Characteristics of Lixisenatide Once Daily Versus Liraglutide Once Daily in Patients with Type 2 Diabetes Insufficiently Controlled on Metformin PDF Free

Download Pharmacodynamic Characteristics of Lixisenatide Once Daily Versus Liraglutide Once Daily in Patients with Type 2 Diabetes Insufficiently Controlled on Metformin Books Free

Download Pharmacodynamic Characteristics of Lixisenatide Once Daily Versus Liraglutide Once Daily in Patients with Type 2 Diabetes Insufficiently Controlled on Metformin Free

Download Pharmacodynamic Characteristics of Lixisenatide Once Daily Versus Liraglutide Once Daily in Patients with Type 2 Diabetes Insufficiently Controlled on Metformin PDF

Download Pharmacodynamic Characteristics of Lixisenatide Once Daily Versus Liraglutide Once Daily in Patients with Type 2 Diabetes Insufficiently Controlled on Metformin Books