Pharmacokinetics and Pharmacodynamics of Antimalarial Drugs Used in Combination Therapy PDF
By:Qigui Li,Mark R. Hickman
Published on 2015-06-04 by Bentham Science Publishers
Malaria takes a great toll on human health and well-being, particularly in tropical regions including Sub-Saharan Africa, Southeast Asia, Oceania and parts of the Americas. In recent years, some Plasmodium strains have become increasingly resistant to all classes of conventional antimalarial drugs currently in use. Researchers have, therefore, stepped up efforts to revise atimalarial drug policies, develop new drugs, and implement new strategies to combat this disease. In order to prevent widespread resistance, antimalarial combination therapies (ACTs) have been deployed and a World Antimalarial Resistance Network has been established as a means of anitimalarial drug resistance surveillance. Artemisinin-based combination therapies have proven to be useful as a replacement for standard regimens. Currently, these ACTs successfully cure patients suffering from uncomplicated malaria with superior efficacy and lower toxicity, but there remains a huge challenge (high mortality rate) associated with treatment of severe malaria. Studies of drug disposition and drug efficacy (PK/PD evaluations) are essential to understanding why drugs work as antimalarials as they illustrate issues with drug resistance, drug safety and drug toxicity that are critical to finding the appropriate drug dose for patients. This eBook illustrates how currently available combination antimalarial drugs can be optimized for effective malaria treatment. Chapters in this book explain methods to select combination drugs based on PK/PD evaluations followed by methods o reduce drug toxicity based on these evaluations. The book also summarizes efforts that are being made by the research community to improve ACT. It is, therefore, a handy reference for medical professionals and pharmacologists working on antimalarial drugs.
This Book was ranked at 14 by Google Books for keyword Pharmacodynamics.
Book ID of Pharmacokinetics and Pharmacodynamics of Antimalarial Drugs Used in Combination Therapy's Books is 8u4ADgAAQBAJ, Book which was written byQigui Li,Mark R. Hickmanhave ETAG "61YPa6Bvs2w"
Book which was published by Bentham Science Publishers since 2015-06-04 have ISBNs, ISBN 13 Code is 9781681080543 and ISBN 10 Code is 1681080540
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