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Preclinical Pharmacodynamic and Pharmacokinetic Studies of Investigated New Drugs PDF
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Published on 1999 by

During this contract, pharmacokinetic, pharmacodynamic, bioavailability, and metabolism studies were conducted on the following compounds under development by the U.S. Army Medical Research Acquisition Activity: the anti-cyanotic agents, WR 242511 and PAHP; the nerve agent antidote, 111-6; the anti-malarial agents, WR 238605, WR 243251 and isomers, WR 250547 and WR 250548, artelinic acid and N-desbutylhalofantrine. Major findings indicated that a metabolite of WR 242511 is responsible for the production of methemoglobinemia; dogs and rats may metabolize PAHP differently; significant clinical and pharmacokinetic interactions do not appear to occur when WR 238605 is given to dogs along with other schizonticidal agents; artelinic acid is extensively metabolized and radioactivity derived from 14Cartelinic acid is widely distributed in rats; the dose of artelinic acid required to elicit a pharmacodynamic effect in rats, as assessed by mortality and clinical signs of toxicity, is almost 20-fold lower when the compound is given intravenously, compared to orally; the pharmacodynamic effects of WR 243251 appear to be predominantly associated with its R-isomer, WR 250547; radioactivity derived from 14CN-desbutylhalofantrine is widely distributed in rats.

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Download Preclinical Pharmacodynamic and Pharmacokinetic Studies of Investigated New Drugs PDF Free

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